منابع مشابه
PxdA helps peroxisomes hitch a ride
< a d d a r t t y p e = " r e l " d o i = " 1 0. 1 0 8 3 / j c b. 2 0 1 5 1 2 0 2 0 " > Salogiannis et al.< / a d d a r t > identify a linker protein that helps peroxisomes hitchhike through the cell on early endosomes. In most eukaryotic cells, organelles and other cargoes move through the cytoplasm along microtubules, using specifi c adaptor molecules to recruit microtubule-based motor protei...
متن کاملOrganelle Transport: Mitochondria Hitch a Ride on Dynamic Microtubules
questions. Why, for example, did the two analytical approaches taken by Lander et al. [8] (a general linear model and a circuit model) come to opposing conclusions?Whichmechanismsmake one hostile habitat, clear-fells, act as a barrier, while the hostile pine plantations enhanced connectivity? Andhowmight theCirce principle apply to the main pollinator taxon, bees (Hymenoptera: Apiformes), which...
متن کاملMorphogens
Hands have five fingers, with each finger different and arranged in a particular order. Obvious perhaps, but the way that this arrangement is achieved during development has intrigued developmental biologists for decades. How do the cells of the hand know whether to form a thumb, index or little finger? More generally, how do cells know where they are within a tissue so that they form the appro...
متن کاملNodal morphogens.
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postul...
متن کاملUnderstanding how morphogens work.
In this article, we describe the mechanisms by which morphogens in the Xenopus embryo exert their long-range effects. Our results are consistent with the idea that signalling molecules such as activin and the nodal-related proteins traverse responding tissue not by transcytosis or by cytonemes but by movement through the extracellular space. We suggest, however, that additional experiments, inv...
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ژورنال
عنوان ژورنال: Nature
سال: 2005
ISSN: 0028-0836,1476-4687
DOI: 10.1038/435030a